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Clinical coding of prospectively identified paediatric adverse drug reactions--a retrospective review of patient records. This study aimed to determine whether ADRs prospectively identified in children admitted to a paediatric hospital were coded appropriately using ICD The electronic admission abstract for each patient with at least one ADR was reviewed.
Of ADRs, 76 Data derived from administrative healthcare databases are not reliable for identifying ADRs by themselves, but may complement other methods of detection. Directory of Open Access Journals Sweden. The validation cohorts included HIV-infected individuals from previous published studies. Area under the receiver operating characteristic ROC curve was calculated. Seventeen of participants developed active TB during a median follow-up period of 5.
Inappropriate dietary eliminations may impair quality of life, affect children's growth and unnecessarily impact on healthcare costs. A definite pattern has not been found yet for patients not reintroducing the food. This study aimed to examine the role of child's nutritional attitudes and maternal anxiety in reintroducing food after a negative OFC.
A prospective study was conducted involving 81 mothers of children with IgE-mediated food allergy. In total, Consumption of the reintroduced food is positively correlated to child's interest in tasting new foods before and after OFC and to changes in child's nutritional habits after OFC.
It is negatively correlated to monotony of the diet after OFC. No correlations were found with other participants' characteristics or maternal anxiety. State anxiety significantly decreased after the OFC. A correlation was found between trait and state anxiety and the degree of change in nutritional habits after OFC. Evaluating child's approach towards food before the OFC is a promising approach to identify patients at risk of food reintroduction failure.
Furthermore, it underlined the importance of reassessing food consumption in all patients after a negative OFC and supporting patients in the reintroduction of food. Syndromic approach to treatment of snake bite in Sri Lanka based on results of a prospective national hospital-based survey of patients envenomed by identified snakes. Russell's vipers Daboia russelii and hump-nosed pit vipers Hypnale hypnale were the most numerous and H. Distinctive clinical syndromes were identified to aid species diagnosis in most cases of snake bite in Sri Lanka where the biting species is unknown.
Although only polyspecific antivenoms are used in Sri Lanka, species diagnosis remains important to anticipate life-threatening complications such as local necrosis, hemorrhage and renal and respiratory failure and to identify likely victims of envenoming by H.
The technique of hospital-based collection, labeling and preservation of dead snakes brought by bitten patients is recommended for rapid assessment of a country's medically-important herpetofauna. Prospective construction and validation of a prognostic score to identify patients who benefit from third-line chemotherapy for metastatic breast cancer in terms of overall survival: the METAL3 Study.
Metastatic breast cancer MBC is an incurable disease and represents a complex therapeutic challenge for oncologists. Despite the possibility of prescribing new agents such as tailored therapy, cytotoxic chemotherapy and hormone therapy remain the major treatments for MBC. Several lines of chemotherapy can be proposed for these patients , but beyond the second-line, evidence of effectiveness is lacking and such treatment has important associated toxicity affecting quality of life QoL.
Prospective data on third-line chemotherapy is very poor. There is no recent retrospective data and it mainly includes single-centre experiences. Moreover, prognostic parameters considered in these retrospective studies are limited to clinico-pathological factors.
METAL3 METAstatic Line 3 is a prospective , multicentric trial designed to prospectively construct a prognostic score including selected clinico-pathological factors, CTC and baseline QoL to identify patients who benefit from third-line chemotherapy for MBC in terms of overall survival training cohort.
Score will then be validated with another cohort validation cohort. The aim of this paper is to review literature data on third-line chemotherapy for MBC and to describe in detail our prospective study. We hope that this prognostic score could be used by physicians to develop new therapeutic strategies when there will be limited benefit of third-line chemotherapy; this score will also help to improve patient information on their outcome.
All rights reserved. Identifying patient risks during hospitalization. Full Text Available Objective: To identify the risks reported at a public institution andto know the main patient risks from the nursing staff point of view. Methods: A retrospective, descriptive and exploratory study. The study included all nurses working in care areas whoagreed to participate in the study.
At the same time, sentinel eventsoccurring in the period from July to July were identified. Results: There were sentinel events reported, and the main risksincluded patient falls, medication errors and pressure ulcers. Sixty-fivenurses were interviewed.
They also reported patient falls, medicationerrors and pressure ulcers as the main risks. Involvement of a multidisciplinaryteam is one of the steps for a successful process. Median follow-up was 5. By computed tomography CT final staging, 18 of 37 patients had a complete response, 18 had a partial response and 1 patient had stable disease.
Hamstra, Daniel A. Methods and Materials: Pretreatment characteristics and treatment details among men were evaluated using a general linear mixed model for their association with measured HRQOL by the Expanded Prostate Cancer Index Composite instrument through 2 years after enrollment.
Baseline bowel score was the strongest predictor for all 2-year endpoints. No other radiation therapy treatment-related variables influenced moderate to big changes in rectal HRQOL. Aspirin use correlated with a clinically significant 4.
Intensity modulated radiation therapy was associated with higher radiation therapy doses to the prostate and lower doses to the rectum but did not independently correlate with bowel HRQOL. Larry; Zietman, Anthony L. SR identified a primary tumor site in 66 CUP patients In the present study we try to highlight prospective mathematics teachers' ability to identify mistakes of sixth grade students related to angle concept. And also we examined prospective mathematics teachers' knowledge of angle concept.
Study was carried out with 30 sixth-grade students and 38 prospective mathematics teachers. Sixth grade students…. The aim of this study was to investigate differences in clinical characteristics among subtypes of TVS using multicenter TIA registry data.
Patients with TIA visiting within 7 days of onset were prospectively enrolled from 57 hospitals between June and December Clinical characteristics were compared between patients with 3 major subtypes of TVS transient monocular blindness [TMB], homonymous lateral hemianopia [HLH], and diplopia. Of patients , 7. Ninety-one patients with 1 of the 3 major subtypes of TVS were included. Some differences in clinical characteristics were found among subtypes of TVS.
Published by Elsevier Inc. Can surveillance systems identify and avert adverse drug events? A prospective evaluation of a commercial application. Computerized monitors can effectively detect and potentially prevent adverse drug events ADEs. Most monitors have been developed in large academic hospitals and are not readily usable in other settings. We assessed the ability of a commercial program to identify and prevent ADEs in a community hospital.
We examined the frequency and types of alerts produced, how often they were associated with ADEs and potential ADEs, and the potential financial impact of monitoring for ADEs. Among 2, patients screened, the application generated high priority alerts. We were able to review alerts at the time they were generated and among these, 30 In all 15 cases, the responsible physician was unaware of the event, leading to a change in clinical care in 14 cases.
Active surveillance used approximately 1. When used as part of an active surveillance program, it can have an impact on preventing or ameliorating ADEs. Screening techniques to identify people at high risk for diabetic foot ulceration: a prospective multicenter trial.
Diabetic foot ulceration is a preventable long-term complication of diabetes. A multicenter prospective follow-up study was conducted to determine which risk factors in foot screening have a high association with the development of foot ulceration.
A total of patients from 3 large diabetic foot centers were enrolled in a prospective study. Neuropathy symptom score, neuropathy disability score NDS , vibration perception threshold VPT , Semmes-Weinstein monofilaments SWFs , joint mobility, peak plantar foot pressures, and vascular status were evaluated in all patients at the beginning of the study.
Patients were followed-up every 6 months for a mean period of 30 months range , and all new foot ulcers were recorded. The sensitivity, specificity, and positive predictive value of each risk factor were evaluated. Patients who developed foot ulcers were more frequently men, had diabetes for a longer duration, had nonpalpable pedal pulses, had reduced joint mobility, had a high NDS, had a high VPT, and had an inability to feel a 5.
On the other hand, the best specificity for a single factor was offered by foot pressures, and the best combination was that of NDS and foot pressures. Univariate logistical regression analysis yielded a statistically significant odds ratio OR for sex, race, duration of diabetes, palpable pulses, history of foot ulceration, high NDSs, high VPTs, high SWFs, and high foot pressures.
Clinical examination and a 5. Identifying organizational cultures that promote patient safety. Safety climate refers to shared perceptions of what an organization is like with regard to safety, whereas safety culture refers to employees' fundamental ideology and orientation and explains why safety is pursued in the manner exhibited within a particular organization.
Although research has sought to identify opportunities for improving safety outcomes by studying patterns of variation in safety climate, few empirical studies have examined the impact of organizational characteristics such as culture on hospital safety climate. This study explored how aspects of general organizational culture relate to hospital patient safety climate.
In a stratified sample of 92 U. The Patient Safety Climate in Healthcare Organizations and the Zammuto and Krakower organizational culture surveys measured safety climate and group, entrepreneurial, hierarchical, and production orientation of hospitals' culture, respectively. We administered safety climate surveys to 18, personnel and organizational culture surveys to a 5, random subsample between March and May Hierarchical linear regressions assessed relationships between organizational culture and safety climate measures.
Aspects of general organizational culture were strongly related to safety climate.
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